This cell type is very small in comparison to the Purkinje cell, but far more numerous. It is estimated that ~2 x 1E9 granule cells exist within the cerebellum, located in the deepest cortical layer of the cerebellum called the granular layer. Granule cells have from three to seven dendrites, receiving signals from the brain stem and cerebral cortex. Axons of the granule cell course vertically through the Purkinje layer and arborize, forming many branches to establish contact with 200 to 500 Purkinje cells. Each Purkinje cell receives approximately 150,000 synaptic inputs from the granule layer.
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